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The most common phytocannabinoid, in addition to THC, is cannabidiol (CBD). It used to be common in native cannabis breeds from Afghanistan and Morocco, for example, but has largely disappeared from recreational cannabis. It is also present in hemp fibers and in some types of seeds, but generally in low quantities. In the medicinal field, the CBD has received increasing attention due to its many therapeutic properties that include pain relief and anti-inflammatory benefits, without causing poisoning or sedation. It also reduces the side effects of THC when administered together, specifically anxiety and tachycardia. Taken together, the two components can give rise to synergy in many applications. Another component of cannabis of interest is tetrahydrocannabivarine (THCV), which is traditionally found in small quantities in the chemical cannabis varieties of Southern Africa. It is currently under investigation as a treatment for metabolic syndrome, often considered as a prelude to the development of type II diabetes. The abundant evidence supports that these low concentration components influence phytocannabinoids in total cannabis preparations by adding their own therapeutic benefits or by decreasing the side effects of THC. Worthy of special mention are limonene, with known antidepressant effects, pinene, which attenuates short-term memory deficits generated by THC, myrcene, which is sedative, and beta-cariophilene, which stimulates the non-psychoactive CB2 receptor causing anti-inflammatory and analgesic effect. Future research will elucidate the relative importance of these agents in various cannabis preparations. About the author: Dr. Ethan Russo is an accredited neurologist who works as a Senior Medical Advisor for GW Pharmaceuticals. In the past he was president of the International Association for Cannabinoid Drugs and currently chairs the International Cannabinoid Reseach Society. The first time he smoked marijuana was in 2008. He was 52 years old and the diagnosis of a disease called fibromyalgia. Noemí Oliveto - now 58 years old, a psychologist at the UBA, a former Buenos Aires legislator - reviews that moment that is impossible to forget: “I was in Caviahue, where I had come to do a treatment. A woman who had gone for the same thing told me about marijuana and invited me a whistle.